Throughout the entire process, educate the patient and family through regular follow-up care and involvement of support groups to cope with physical, emotional, and spiritual stress. 2010, 111112. Oncol. Received: 08 June 2021; Accepted: 15 September 2021;Published: 05 October 2021. doi: 10.1371/journal.pone.0068782, Keywords: anaplastic oligodendroglioma, PCV, IDH mutation, procarbazine, lomustine, vincristine, temozolomide, Citation: Bou Zerdan M and Assi HI (2021) Oligodendroglioma: A Review of Management and Pathways. For example, a test may look at the changes in the tumor cells' genetic material, called DNA. 0000014853 00000 n 2017:7082696. Some of these alterations have correlated with prognosis and response to treatment. A neuropathologist should then review the tumor tissue. Neuro Oncol. Contribute to Human FUBP1 and CIC Mutations in. Paleologos NA, Vick NA, Kachoris JP. 27, 149155. Computed tomography scan of a low-grade oligodendroglioma. Ueki, K., Ono, Y., Henson, J. W., Efird, J. T., von Deimling, A., and Louis, D. N. (1996). 0000127092 00000 n Neuropathol. Oligodendroglioma is most common in adults, but it can happen at any age. The treatment modalities have shifted over time, and recent studies are considering immunotherapy as an option as well. (2013b). This content does not have an English version. Int. Pathophysiology Cell (or cells) of origin for oligodendroglioma remains unknown IDH mutation is likely the initiating event (driver mutation), which precedes 1p / 19q codeletion ( Adv Anat Pathol 2015;22:50, Biomed Res Int 2014;2014:540236 ) IDH mutations give rise to metabolic alterations, with increased production of 2-hydroxyglutarate (2HG) (2016). 0000003918 00000 n This means it begins in the brain or spinal cord. Upon reanalysis of RTOG 9802 after molecular classification, AO patients with IDH-mutated tumors actually showed a survival benefit when treated with PCV chemotherapy (Cairncross et al., 2014). . Two studies evaluating irinotecan treatment for recurrent malignant glioma using an every-3-week regimen. eCollection 2023 Apr. 2023 Feb 28;13(5):914. doi: 10.3390/diagnostics13050914. Your care team uses this information to create a treatment plan. [3] This risk classification may change in the future as our understanding of the contributions of genetic markers to survivability evolves. (2013) was the first to conduct a meta-analysis on PFS and OS in gliomas based on IDH mutations. The CODEL study is a phase 3 study whereby 36 patients with newly diagnosed grade III oligodendrogliomas were randomized to receive RT alone (Arm A), RT with concomitant and adjuvant TMZ (Arm B) or TMZ alone (Arm C) (Jaeckle et al., 2021). A., Taphoorn, M. J., Kros, J. M., Kouwenhoven, M. C., Delattre, J.-Y., et al. 19, 55135522. Diffuse leptomeningeal glioneuronal tumour (1p/19q codeletion present, but IDH wildtype). J. Neurooncol. Pitt MA, Jones AW, Reeve RS, Cowie RA. Oncol. The cellular density is moderate to high, and the fried-egg appearance dominates the histologic features. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. 22 (5):665-674. Re-analysis of some trials prior to the 2016 WHO brain tumor classification has given further insight into some molecular pathways that were previously poorly defined or investigated. Some oligodendrogliomas have eosinophilic cytoplasm with focal perinuclear clearing. Chem. Relative frequency of histopathologically diagnosed, Relative frequency of histopathologically diagnosed oligodendroglial and oligoastrocytic tumors in the spectrum of, Common histopathologic patterns encountered in, Common histopathologic patterns encountered in classic (IDH mutant, 1p19q codeleted) oligodendrogliomas include: a, Less common and sometimes diagnostically, Less common and sometimes diagnostically confusing histopathologic patterns encountered in classic (IDH mutant,, Diffuse gliomas: from histopathologically to, Diffuse gliomas: from histopathologically to molecularly defined entities. The tissue sample goes to a lab for testing. Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial. 110, 60216026. 0000013354 00000 n Nature 483, 479483. CORE - Aggregating the world's open access research papers J. Clin. 0000016053 00000 n Oligodendroglioma and oligoastrocytoma belong to a group of brain tumors called gliomas. TERT mutations in glioma are often found within the promoter region. Focused Oligodendroglioma with stained slides of pathology. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Infographic: Molecular Classification of Gliomas, Intraoperative magnetic resonance imaging (iMRI), Research provides critical information about the size and growth speed of gliomas, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. doi: 10.1101/gad.13.12.1501. Chan, A. This comes with a risk of sacrificing important brain centers and hence compromising functionality and quality of life. 31, 774786. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Stephen A Berman, MD, PhD, MBA is a member of the following medical societies: Alpha Omega Alpha, American Academy of Neurology, Phi Beta KappaDisclosure: Nothing to disclose. Contributed by Jared T. Ahrendsen, M.D., Ph.D. Dysembryoplastic neuroepithelial tumor (DNET), WHO Classification of Tumours Editorial Board: Central Nervous System Tumours, 5th Edition, 2022, CNS WHO 2021 definition: diffusely infiltrating glioma with, Diffusely infiltrating glial neoplasm with, Morphology resembles nonneoplastic oligodendrocytes with round monotonous nuclei and perinuclear halos, Chicken wire vasculature, microcalcifications and microcysts are characteristic (, Astrocytic differentiation does not preclude diagnosis if molecular features are present, Small gemistocytes (mini gemistocytes) with rounded bellies of eosinophilic, eccentrically placed cytoplasm are occasionally seen, especially in grade 3 tumors (, Presence of other atypical features (including multinucleated giant cells, sarcomatous features, neurocytic differentiation or ganglion-like cells) does not preclude a diagnosis of oligodendroglioma if the requisite molecular features are present (, Most epidemiologic data is based on histologic, rather than molecular, classification of oligodendroglioma, Incidence of 0.23 cases per 100,000 population in the United States (, Incidence of CNS WHO grade 3 oligodendroglioma is 0.11. doi: 10.1007/BF00177478. 31, 344350. J. Clin. 123, 853860. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. 0000225404 00000 n Two of 10 central neurocytomas and 2/10 clear cell ependymomas showed focal OLIG2 expression. J. Clin. (1994). Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. 0000141631 00000 n 0000276291 00000 n ; Fiao, C.; Garca, JF. 2005 Jul. Zou et al. Where this happens in the body depends on which parts of the brain are affected by the tumor. 23, 457467. D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats. We Choose to Fight through Advocacy, Two-time Oligodendroglioma Survivor: Never Give Up Hope, NCI-CONNECT Rare Brain and Spine Tumor Network, U.S. Department of Health and Human Services. Br J Neurosurg. Celli P, Nofrone I, Palma L, et al. J. Biol. [QxMD MEDLINE Link]. doi: 10.3171/2016.11.jns161974, Alms, D., Fedrowitz, M., Rmermann, K., Noack, A., and Lscher, W. (2014). Cell 81, 323330. Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy. (WC/jensflorian), Combined losses of 1p and 19q both and presence of IDH1 mutation in codon 132 or IDH2 mutation in codon 172 is required for final diagnosis and is prognostic and therapeutic relevant:[15][16][17]. Oligodendroglioma, IDH-mutant and 1p/19q-codeleted, WHO CNS Grade 2 (ICD-O: 9450/3). Mason WP. J. Neurosci. 18, 15291537. Their good prognosis relative to other parenchymal tumors probably stems from inherently less aggressive biological behavior and a favorable response to radiation and chemotherapy. J. Clin. Suzuki SO, Kitai R, Llena J, Lee SC, Goldman JE, Shafit-Zagardo B (May 2002). Ruas, M., and Peters, G. (1998). Exp. Development. 19, (Suppl._5) v1v88. Histologically, oligodendroglial tumors show sheets of isomorphic round nuclei with a clear cytoplasmthe classic fried egg appearance. Your oncologist might recommend a combination of medications - procarbazine, lomustine, and vincristine. This tumor, previously diagnosed as GBM-O, WHO grade IV featured mostly cells resembling astrocytoma (, Example where molecular reclassification does not affect tumor grade. Seizure characteristics and control following resection in 332 patients with low-grade gliomas. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of -ketoglutarate-dependent dioxygenases. Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, et al. The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous author Subramanian Hariharan, MD to the development and writing of this article. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE1NjY5OS1vdmVydmlldw==. Interestingly, some tumors exhibited p16 hyperexpression without any chromosome 9p alterations and this was associated with a shorter EFS and OS. Cancer Res. MRI of an oligodendroglioma in the brain. Consequences of IDH1/2 mutations in gliomas and an assessment of inhibitors targeting mutated IDH proteins. 8600 Rockville Pike Surgery to remove the tumor. 0000015277 00000 n Phase 2 study of weekly irinotecan in adults with recurrent malignant glioma: final report of NABTT 97-11. IDH1 mutations seem to be at the core of this tumorigenesis (Johnson et al., 2014). (Jun 2016). 9, 314318. NCI CPTC Antibody Characterization Program, Agnihotri S, Aldape KD, Zadeh G. Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma. Lancet 390, 16451653. Oligodendrogliomas are primary brain tumours that are a type of glioma. CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas. Adjuvant TMZ has also been shown to be effective with better tolerability and less toxicity (van den Bent et al., 2003; Brandes et al., 2006). Giannini, C.; Scheithauer, BW. 109, 835841. The https:// ensures that you are connecting to the 2002 Apr 15. Correlations Between O6-Methylguanine DNA Methyltransferase Promoter Methylation Status, 1p and 19q Deletions, and Response to Temozolomide in Anaplastic and Recurrent Oligodendroglioma: A. J. Clin. doi: 10.1097/00006123-199811000-00035, Taliansky-Aronov, A., Bokstein, F., Lavon, I., and Siegal, T. (2006). Oligodendrogliomas are molecularly defined by the presence of complete deletion of the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) (1p/19q co-deletion). Meanwhile, smart integration of morphological and molecular information will lead to recognition of biologically much more uniform groups within the spectrum of diffuse gliomas and thereby facilitate tailored treatments for individual patients. doi: 10.1016/s1567-133x(01)00022-9, van den Bent, M. J., Baumert, B., Erridge, S. C., Vogelbaum, M. A., Nowak, A. K., Sanson, M., et al. A., Tosoni, A., Cavallo, G., Reni, M., Franceschi, E., Bonaldi, L., et al. Aldape, K.; Burger, PC. Recurrence following neurosurgeon-determined gross-total resection of adult supratentorial low-grade glioma: results of a prospective clinical trial. Oligodendrogliomas. Major drugs utilized in the treatment of AO. This image reveals a well-demarcated, left frontal hypoattenuating lesion with a small calcification. Smith, J. S., Perry, A., Borell, T. J., Lee, H. K., OFallon, J., Hosek, S. M., et al. (2020), gross tumor resection (GTR) was done in 43 of 88 patients. 0000126977 00000 n They are responsible for histone methylation on lysine residues. Sci. 0000245213 00000 n 129, 19. 507 0 obj <> endobj Science 289:905. Temozolomide for low-grade gliomas: predictive impact of 1p/19q loss on response and outcome. 57(2):172-5. Lower grade gliomas. The earliest regimen used for the treatment of these tumors was procarbazine, lomustine, and vincristine. (2012). No use, distribution or reproduction is permitted which does not comply with these terms. Bethesda, MD 20894, Web Policies (2019). It can also stimulate the activity of EGLN leading to decreased HIF levels. ; Hernndez-Lan, A. et al. The oligodendroglioma, a relatively indolent form of diffuse gliomas thought to originate in oligodendrocytes, has never demonstrated myelin formation on electron microscopy nor shown a constant expression of myelin-related proteins. 0000225381 00000 n Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance. (2003). These alterations have correlated with a shorter event free survival (EFS; 29 vs. 53 months, p < 0.0001) and OS (48 vs. 83 months, p < 0.0001). 507 83 ; Mork, S.; Graeber, MB. Afterward in 2001, Chinot et al. 0000230693 00000 n A chemotherapy called temozolomide is also being studied in clinical trials. Copyright 2021 Bou Zerdan and Assi. Options Neurol. ; Kros, JM. Response rate and prognostic factors of recurrent oligodendroglioma treated with procarbazine, CCNU, and vincristine chemotherapy. Sahm, F., Koelsche, C., Meyer, J., Pusch, S., Lindenberg, K., Mueller, W., et al. Acta Neuropathol. 1995. Please confirm that you would like to log out of Medscape. Radiation therapy is sometimes used after surgery and may be combined with chemotherapy. Neuro Oncol. Louis, DN. 2005 May. Abstract Aims: We performed an immunohistochemical analysis of alpha-thalassaemia/mental retardation syndrome X-linked (ATRX) expression in adult diffuse gliomas, with reference to clinicopathological and genetic features, to determine the utility of this analysis in diagnostic practice. [QxMD MEDLINE Link]. K.-Y., Pang, J. C.-S., Chung, N. Y.-F., Li, K. K.-W., Poon, W. S., Chan, D. T.-M., et al. However, upon multivariate analysis there was no significant difference in overall survival (OS). ROS and brain gliomas: an overview of potential and innovative therapeutic strategies. 0000245854 00000 n (2010). NCT03971734 aims to determine the optimal dose of Regadenoson which alters the integrity of the Blood-Brain-Barrier in patients with high grade gliomas. (2011). 29, 1139911408. Table 1 outlines some information related to the major drugs used in treatment. Phase II study of topotecan in patients with recurrent malignant glioma. doi: 10.1200/jco.1999.17.5.1516, Fu, H., Cai, J., Clevers, H., Fast, E., Gray, S., Greenberg, R., et al. Koike H, Morikawa M, Ishimaru H, Ideguchi R, Uetani M, Miyoshi M. Diagnostics (Basel). 7, 112. The PFS and OS were 3.4 and 18.8 months, respectively. CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014. Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study. 2013;126:267276. Our syndication services page shows you how. Classic histologic image of oligodendroglioma. 61(9):1862-6. Cancers (Basel). While increasing the risk of toxicity, concurrent TMZ is currently being assessed in comparison to adjuvant treatment in astrocytic tumors (van den Bent et al., 2017). doi: 10.1007/s00401-016-1545-1, Lu, C., Ward, P., Kapoor, G., Rohle, D., Turcan, S., Abdel-Wahab, O., et al. Brown R, Zlatescu M, Sijben A, Roldan G, Easaw J, Forsyth P. The use of magnetic resonance imaging to noninvasively detect genetic signatures in oligodendroglioma. Oligodendrogliomas can spread to other areas of the CNS through cerebrospinal fluid (CSF), but is uncommon. An Inhibitor of Mutant IDH1 Delays. doi: 10.1007/s00401-012-0993-5, Sasaki, H., Zlatescu, M. C., Betensky, R. A., Ino, Y., Cairncross, J. G., and Louis, D. N. (2001). *Correspondence: Hazem I. Assi, ha157@aub.edu.lb, https://doi.org/10.3389/fnmol.2021.722396, Creative Commons Attribution License (CC BY), Division of Hematology and Oncology, Department of Internal Medicine, Naef K. Basile Cancer Institute, American University of Beirut Medical Center, Beirut, Lebanon. As expected, patients with an IDH mutation and 1p19q co-deletion showed significant benefit in OS. Sahm F, Koelsche C, Meyer J, Pusch S, Lindenberg K, Mueller W, Herold-Mende C, von Deimling A, Hartmann C. Acta Neuropathol. The spinal cord is a long thin structure that sits in the spinal column at the back of the body. Kang SG, Kim JH, Nam do H, Park K. Clinical and radiological prognostic factors of anaplastic oligodendroglioma treated by combined therapy. Oncol. Similarly in a retrospective study by Fujii et al. Through the formation of homo- and hetero-dimers with other bHLH transcription factors, TCF12 modulates the transcription of specific genes that are intrinsic to the oligodendrocyte lineage (Fu et al., 2009) and are involved in neural development (Uittenbogaard and Chiaramello, 2002). doi: 10.1200/JCO.2012.43.2229. CODEL: phase III study of RT, RT+ TMZ, or TMZ for newly diagnosed 1p/19q codeleted oligodendroglioma. doi: 10.1371/journal.pone.0193213, Ohgaki, H., and Kleihues, P. (2009). 9, 860864. The PFS HR was 3.33 with a 95% CI 1.318.45 (P = 0.011) while the OS HR was 2.78 with a 95% CI 0.5813.22 (P = 0.20) (Jaeckle et al., 2021). Dubbink HJ, Atmodimedjo PN, Kros JM, French PJ, Sanson M, Idbaih A, Wesseling P, Enting R, Spliet W, Tijssen C, Dinjens WN, Gorlia T, van den Bent MJ. An independently validated survival nomogram for lower-grade glioma. Although 9p losses can be found in many gliomas, they more commonly occur in higher grade tumors (grades 3 and 4), which make the CDKN2A gene or p16 protein (CDKN2A product) potential players involved in the malignant progression and anaplastic transformation of low-grade gliomas into higher grades (He et al., 1995; Ueki et al., 1996; Watanabe et al., 2001). 19 (suppl_5):v1-v88. Procarbazine, CCNU, vincristine (PCV) chemotherapy for benign oligodendroglioma. 13:861-873. Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study. Am. Few calcifications are present. 2008 Aug. 15(8):946-9. J. Pathol. 56-64. Biochim. 59, 495503. On magnetic resonance imaging, he was considered to have disease progression. 0000005528 00000 n 293, 97479758. 2010, 279296. Neurol. Elens, I., De Vleeschouwer, S., Pauwels, F., and Van Gool, S. (2012). There are several different types of gliomas. This tumor, previously diagnosed, Example where molecular reclassification does, Example where molecular reclassification does not affect tumor grade. The surgeon might ask questions and monitor the activity in your brain as you reply. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. It has been observed that in IDH-mutant cell lines, repressive histone methylation precedes global DNA hypermethylation. doi: 10.1126/science.1170944, Zou, P., Xu, H., Chen, P., Yan, Q., Zhao, L., Zhao, P., et al. Neurosurgery 59, 12031214. Cairncross JG, Berkey B, Shaw E. Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendrogliomas: intergroup Radiation Therapy Oncology Group Trial 9402. 0000141681 00000 n Pathol. Both authors have read and approved the final manuscript. Bannykh, SI. Although a mutated IDH1 cannot generate NADPH since it has lost its normal catalytic activity, it gains the function of producing D-(R)-2-hydroxyglutarate. 0000280922 00000 n Uhm, J. Table 1. Multidrug resistance proteins expression in glioma patients with epilepsy. Missing chromosomes (parts of your genes) can cause cells to grow into a tumor. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., Oligodendroglioma Diagnosis and Treatment was originally published by the National Cancer Institute.. [QxMD MEDLINE Link]. 0000008234 00000 n Curr Treat Options Neurol. Clin Cancer Res. <<950B2C5CEB56DC43B0B6FC5D5B108F3A>]/Prev 655139/XRefStm 2967>> (1999). Molecular alterations associated with tumor progression: Glioma CpG island methylator phenotype (G CIMP) (. 131, 803820. However, analysis of other trials such as the EORTC 26951 did not reveal a correlation between IDH mutations and survival in patients with astrocytic tumors (grade II) (van den Bent et al., 2010, 2013a). https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1425. Oncol. In 8 recurring oligodendrogliomas, the number of GFAP positive tumour cells was the same in the primary tumour and in its recurrence. The retinoblastoma protein and cell cycle control. Clin Cancer Res. Oncometabolite D-2-hydroxyglutarate inhibits ALKBH DNA repair enzymes and sensitizes IDH mutant cells to alkylating agents. 0000230615 00000 n While usually unexpressed in mature cells, cancer cells make use of this enzyme to promote their survival and increase proliferation. Natl. If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. doi: 10.1007/s11095-013-1264-4, Amankulor, N. M., Kim, Y., Arora, S., Kargl, J., Szulzewsky, F., Hanke, M., et al. Front. Grade 3 tumors have a median age at diagnosis that is 510 years older than grade 2 tumors. Accounting to up to 5% of all neuroepithelial tumors ( Ostrom et al., 2017 ), oligodendroglial tumors have an incidence rate of around 1,000 new cases per year in the United States. 17, 12481260. This microdevice will be used for 8 intratumor drugs: TMZ, Lomustine, Irinotecan, Carboplatin, Lapatinib, Osimertinib, Abenaciclib, and Everolimus. Cancer. Roger E McLendon, MD is a member of the following medical societies: American Association of Neuropathologists, College of American Pathologists, Society for Neuro-OncologyDisclosure: Nothing to disclose. Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities. Advances in the biology and treatment of oligodendrogliomas. J. Clin. May have neuronal "islands" (Synapto +ve, NeuN +ve). Oligodendroglioma is considered the third most common glioma accounting for 2%-5% of primary brain tumors and 5%-18% of all glial neoplasms 8. 2-HG can inhibit alpha-KG dependent dioxygenases and cause epigenetic alterations (Xu et al., 2011). doi: 10.1007/BF00177439, Mason, W. P., Krol, G. S., and DeAngelis, L. M. (1996). [1] . The fifth edition of WHO classification recognizes two tumor subtypes: The terminology anaplastic oligodendroglioma or oligoastrocytoma is depreceated. There are 11 ongoing clinical trials recruiting patients with AO. Glioblastoma with oligodendroglioma component (GBM-O): molecular genetic and clinical characteristics. (WC/jensflorian), Demonstration of IDH1 R132H mutation in oligodendroglioma. Relative frequency of histopathologically diagnosed oligodendroglial and oligoastrocytic tumors in the spectrum of glial tumors of the CNS: Common histopathologic patterns encountered in classic (IDH mutant, 1p19q codeleted) oligodendrogliomas include: Less common and sometimes diagnostically confusing histopathologic patterns encountered in classic (IDH mutant, 1p19q codeleted) oligodendrogliomas include: Diffuse gliomas: from histopathologically to molecularly defined entities. Cancer 91, 417422. However, we cannot answer medical or research questions or give advice. 44(Suppl 2):A262-A263. The goal of surgery is to obtain tissue to determine the tumor type and to remove as much tumor as possible without causing more symptoms for the person. Mason WP, DeAngelis LM. The wildtype (WT) TERT group was associated with good prognosis only in IDH1/IDH2 WT (IDH-WT) grade II/III astrocytomas. The main function of the IDH1 and IDH2 enzymes is the oxidative decarboxylation of isocitrate to alpha-ketoglutarate. Resection and immunotherapy for recurrent grade III glioma. Gittleman H, Sloan AE, Barnholtz-Sloan JS. The brain and spinal cord are made up of specialized cells called glial cells and neurons. Eight of 10 central neurocytomas, all clear cell meningiomas and 8/10 clear cell ependymomas were negative for OLIG2. Predictors of seizure freedom after resection of supratentorial low-grade gliomas: a review. Infiltration of immune cells, specifically T cells, were also reduced in these tumors (Amankulor et al., 2017; Kohanbash et al., 2017). For nearly a century, the diagnosis and grading of oligodendrogliomas and oligoastrocytomas has been based on histopathology alone. (2018) conducted a Surveillance, Epidemiology, and End Results (SEER)-based analysis in 2017 and showed that GTR was not associated with improved survival in patients with WHO grade II and grade III oligodendrogliomas compared to patients with anaplastic astrocytomas and glioblastomas. 19, 6974. This co-deletion, along with the IDH mutation, enables a tumor to be classified as an oligodendroglioma according to the WHO 2016 criteria (Louis et al., 2016). Schold SC, Burger PC, Minna JD, et al. The patient sustained a disease-free response to nivolumab at least 12 months after surgery. 0000144092 00000 n Jorge C Kattah, MD is a member of the following medical societies: American Academy of Neurology, American Neurological Association, New York Academy of SciencesDisclosure: Nothing to disclose. These cells make a substance that protects nerve cells and helps with the flow of electrical signals in the brain and spinal cord. doi: 10.1093/jnen/60.12.1181. ; Tihan, T.; Lin, D.; McDonald, W.; Nigro, J.; Feuerstein, B.; Jackson, S.; Cohen, K. et al. The earliest reported results of the chemotherapy regimens, procarbazine, lomustine (CCNU), and vincristine (PCV), in AO were reported by Cairncross et al. [2]. Anaplastic oligodendroglioma. The HR was 3.12 with a 95% CI of 1.267.19 (P = 0.014) (Jaeckle et al., 2021). Elsevier; 2023. https://www.clinicalkey.com. Brain Neurorehabil. Wiestler, B.; Capper, D.; Hovestadt, V.; Sill, M.; Jones, DT. (2012). Jain SU, Do TJ, Lund PJ, et al. If you want to understand your prognosis, talk to your doctor. 10, 295307. PNET Survivor Shares Coping Tips Oncol. Moreover, no mutations were found in ERCC6 exon 2 and only two patients had a chemotherapeutic response, but with unexpected short survival times. Proc. 0000017251 00000 n "Oligodendrogliomas: reproducibility and prognostic value of histologic diagnosis and grading.". The site is secure. Neurol. Oligodendrogliomas with vascular proliferation and significant mitotic activity are best considered to be anaplastic oligodendrogliomas (World Health Organization [WHO] grade III). The frequency of these alterations was much higher in grade III AO as compared to grade II oligodendroglioma. For patients with astrocytic tumors, EORTC26951 and RTOG9402 did not show any benefit of PCV with RT. 0000144833 00000 n Find doctors and nurses with experience treating this tumor. 21, 251255. Wick, W., Hartmann, C., Engel, C., Stoffels, M., Felsberg, J., Stockhammer, F., et al. In addition to being a surrogate for oligodendroglial lineage, TERT mutations seem to have some prognostic significance (Dahlin et al., 2016). 2020 May 15. IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group. (2016). (2000b). [QxMD MEDLINE Link]. 0000004228 00000 n J. Neurosci. 2004 Dec. 17(6):675-80. The relative 5-year survival rate for oligodendroglioma is 74.1% but know that many factors can affect prognosis.

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